MedRead Journal of Gastroenterology

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Mechanism underlying effect of autophagy on interleulin-1Beta

Published on: 2020-04-13

Abstract

Autophagy has been linked to myriad biological processes as a response to nutritional deprivation, hypoxia and stress conditions in general. Moreover, autophagy has a potentially pivotal role to play in the regulation of inflammatory responses. In particular, autophagy regulates all kinds of cytokines, especially IL-1β. This review focus specifically on the role of autophagy in regulation the transcription, secretion, signaling of IL-1β. and the consequences of these important functions.

Keywords

Autophagy; ATG16L1; IL-1Beta; Immune response; ROS